Witryna15 sty 2024 · Quinone hybrids as antimalarial agents. In the last two decades, ... The common 1,4-naphthoquinone core binds with I172, I263, and V532 amino acid residues through hydrophobic interactions and the C-2 isoprenyl unit of the 1,4-napthoquinone core shows interactions with F188, V223, F227, and Y528 amino acids. ... WitrynaA new class of 1,4-naphthoquinone hybrids (37) which contain phenylamino-phenylthio moieties as significant counterparts demonstrated major antibacterial activity against bacterial strains Staphylococcus aureus, Listeria monocytogenes, E. coli, P. aeruginosa, Salmonella bongori and Klebsiella pneumoniae. 57–59) Two naphthoquinone …
(PDF) Synthesis and Antimalarial Activity of Lawsone
Witrynalian host [8,9], and several antimalarial drugs show specificity for parasite CoQ, including the hydroxynaphthoquinones [10–12]. Atovaquone, an inhibitor of Complex III (or bc 1 … WitrynaIn this study, some novel 2-hydroxy-1,4-naphthoquinone-4-hydroxyaniline hybrid Mannich bases were designed, synthesized and eva luated for in vitro antimalarial … magna media credentials
1,4-Naphthoquinones: Some Biological Properties and Application
WitrynaSynthesis and Evaluation of 2-Hydroxy-1,4-naphthoquinone Derivatives as Potent Antimalarial Agents. Chemical and Pharmaceutical Bulletin 2024, 69 (3) , ... In vivo … WitrynaNatural products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these natural products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged … Witryna20 paź 2015 · A novel series of 1,4-naphthoquinones (33-44) tethered by open and closed chain sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and antimalarial activities. All quinone-sulfonamide derivatives displayed a broad spectrum of cytotoxic activities against all of the tested cancer cell lines … magna meditech