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Topbp1

Webまた、脊椎動物のdpb11ホモログであるtopbp1においても、酵母のdpb11同様、ginsと結合し複製 開始 に重要な働きをしている領域、すなわち機能的に同じ働きを持つ領域を見出しました。 combined anti-acid-fast bacterial agent, screening ... Web1. apr 2024 · TopBP1 is an important protein for activating ATR following replication stress. To study TopBP1 regulation, we screened a library of USP superfamily members to …

Functions of TopBP1 in preserving genome integrity during mitosis

Web21. dec 2024 · Disrupting MDC1–TOPBP1 binding causes mitotic radiosensitivity and genome instability 12. Adam et al. 4 reported that CIP2A is essential for the mitosis-specific recruitment of TOPBP1 to ... DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name. TOPBP1 is involved in a variety of nuclear specific … Zobraziť viac BRCT domains The TOPBP1 gene encodes a scaffold protein which facilitates interactions between different proteins at specific times and locations. It accomplishes these interactions with … Zobraziť viac Cancer Changes in TOPBP1 gene expression are associated with breast cancer, glioblastoma, non-small cell lung cancer, and Zobraziť viac • Yamane K, Tsuruo T (September 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA". Oncogene. 18 (37): 5194–5203. doi:10.1038/sj.onc.1202922. PMID 10498869. • Mäkiniemi M, … Zobraziť viac DNA damage repair TOPBP1 was first identified as a DNA damage protein through its association with BRCA1, which is a protein heavily implicated in breast cancer pathology. TOPBP1 was found in complex with BRCA1 at sites … Zobraziť viac • DNA damage repair • Ataxia-telangiectasia mutated and RAD3-related (ATR) • BRCA1 Zobraziť viac brick covered porch https://veteranownedlocksmith.com

Mutant p53 perturbs DNA replication checkpoint control through TopBP1 …

Webpred 15 minútami · Using this approach, we identified a set of genomic loci within the proximal promoter region of significantly down-regulated genes TOPBP1, ZHX2, BCL2L1 and CCR1, which were subsequently analysed using ChIP-qRT-PCR (Additional file 1: Fig. S1). i-BET858 treatment caused minor changes in BRD2, BRD3 and BRD4 enrichment in the … Web3. okt 2024 · TopBP1 contains eight BRCA1 carboxyl-terminal (BRCT) phosphopeptide recognition motifs and an ATR-activating domain (AAD) (3, 4). TopBP1 utilizes its BRCT … Web18. okt 2024 · CG和non-CG甲基化是否可以协同调控植物发育，它们同时丢失会对植物正常发育产生什么影响还有待探究。. 2024年10月16日，New Phytologist杂志在线发表了蛋白质与植物基因研究国家重点实验室、北京大学现代农学院钱伟强研究团队题为“Deciphering the synergistic and ... brick crack repair bunnings

TopBP1 assembles nuclear condensates to switch on ATR signaling

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Topbp1

TOPBP1 - Wikipedia

Web5. máj 2024 · Consequently, hypomethylated TOPBP1 facilitates RAD9 (RADiation sensitive 9) binding and chromatin loading of the TOPBP1-RAD9 complex to fully activate ATR and thus safeguard the genome and protect cells against replication stress. Our study uncovers a demethylation and phosphorylation code that controls the assembly of TOPBP1 … Web大肠杆菌(o157：h7)pcr检测试剂盒公司正在销售的产品：小反刍兽疫病毒pcr检测试剂盒供应美人鱼发光杆菌pcr检测...

Topbp1

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Web16. júl 2024 · In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei ... Web11. nov 2024 · h, Quantification of CIP2A and HA-TOPBP1 mitotic IRIF in DLD1 cells expressing variants of sgRNA-resistant TOPBP1 (TOPBP1*) or EV encoding only the HA …

WebTopBP1 has been shown to prevent replication associated DNA damage during neurogenesis (8), and to interact with mutant p53, mediating mutant p53 gain-of-function activity such as growth promotion and resistance to chemotherapeutic drugs (9). Phosphorylation of TopBP1 at Ser1159 by Akt regulates TopBP1 oligomerization and … WebTOPBP1 INFORMATION. Proteini. Full gene name according to HGNC. DNA topoisomerase II binding protein 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TOPBP1 (Dpb11, KIAA0259, TOP2BP1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).

Web24. apr 2024 · TopBP1 contains nine BRCA1 carboxyl-terminal (BRCT) domains with distinct functions in DNA replication initiation, ATR activation, and transcription ().TopBP1 binds to Cdk2-phosphorylated Treslin/TICRR (TopBP1-interacitng, checkpoint, and replication regulator) to facilitate loading of Cdc45 onto replication origins (12, 13).Cdk2 … Web18. mar 2024 · TopBP1 phase separation in vitro occurred also in the complex environment of a nuclear extract, where multiple homotypic and heterotypic interactions could …

WebHuman TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …

Web1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation.TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become … brick crack repairWeb1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome … brick crack repair kitWeb16. mar 2009 · TopBP1 overexpression might contribute to treatment resistance in breast cancer therapy by way of repressing E2F1- and p53-mediated apoptosis, both being required for adequate treatment response. This hypothesis will need to be tested in prospective clinical trials. Whether TopBP1 is an independent prognostic marker for aggressive breast … covering formica countertopsWeb附件： 2011年度浙江省自然科学基金拟资助 省杰出青年科学基金项目清单 项目编号 项目名称 申请者 依托单位 r1110003 brickcraft cedar creekWeb31. júl 2024 · TopBP1 is a DNA repair protein important for the activation of the ATR kinase and DNA replication. TopBP1 contains nine BRCA1 C terminal (BRCT) domains that interact with a variety of phosphorylated proteins [50,51]. The sixth BRCT domain of TopBP1 interacts with phosphorylated E2F1 [32,50,51,52]. brick crack stitchingWebFor Flag-TopBP1 transfection, cells were plated 24 h before transfection in 100 mm dishes at 1 × 10 6 cells. 12.5 μg of pcDNA3-TopBP1 was mixed with 25 μl of Polyethylenimine (1 mg/ml) (Polysciences) in a total volume of 550 μl for each transfection. The pcDNA3-TopBP1 plasmid was generously provided by Dr. Weei-Chen Lin . After 48 h, the ... brick crack fillerWeb18. máj 2010 · Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and … brick crack sealer